FRMD8 promotes inflammatory and growth factor signalling by stabilising the iRhom/ADAM17 sheddase complex

Many intercellular signals are synthesised as transmembrane precursors that are released by proteolytic cleavage (‘shedding’) from the cell surface. ADAM17, a membrane-tethered metalloprotease, is the primary shedding enzyme responsible for the release of the inflammatory cytokine TNFα and several E...

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Detalhes bibliográficos

Principais autores:	Ulrike Künzel, Adam Graham Grieve, Yao Meng, Boris Sieber, Sally A Cowley, Matthew Freeman
Formato:	Artigo
Idioma:	Inglês
Publicado em:	eLife Sciences Publications Ltd 2018-06-01
coleção:	eLife
Assuntos:	iRhom rhomboid inflammation ADAM17
Acesso em linha:	https://elifesciences.org/articles/35012
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