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Okadaic Acid Activates JAK/STAT Signaling to Affect Xenobiotic Metabolism in HepaRG Cells

Okadaic acid (OA) is a marine biotoxin that is produced by algae and accumulates in filter-feeding shellfish, through which it enters the human food chain, leading to diarrheic shellfish poisoning (DSP) after ingestion. Furthermore, additional effects of OA have been observed, such as cytotoxicity....

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Principais autores: Leonie T. D. Wuerger, Felicia Kudiabor, Jimmy Alarcan, Markus Templin, Oliver Poetz, Holger Sieg, Albert Braeuning
Format: Artigo
Sprog:Inglês
Udgivet: MDPI AG 2023-02-01
Serier:Cells
Fag:
okadaic acid
HepaRG cells
CYP enzymes
NF-κB
JAK/STAT
inflammation
Online adgang:https://www.mdpi.com/2073-4409/12/5/770
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