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ATP7B-maintained copper stores in myeloid progenitors are required for functional maturation of neutrophils

Summary: Copper (Cu) is essential for innate immunity; however, how neutrophils regulate Cu homeostasis to support their functions remains unclear. We found that myeloid progenitors express abundant Cu-transporter ATP7B targeted to distinct vesicles and store Cu in vesicles. During neutrophil differ...

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Principais autores: Som Dev, Yu Wang, Moonjung Jung, Yingze Ma, Sepehr Mani, Ekaterina Kabin, Ridzky Yuda, Yixuan Dong, Martina Ralle, James P. Hamilton, Svetlana Lutsenko
Formato: Artigo
Idioma:Inglês
Publicado: Elsevier 2026-02-01
Series:Cell Reports
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Acceso en liña:http://www.sciencedirect.com/science/article/pii/S2211124726000331
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