Safety and preservation of cardiac function following therapeutic vaccination against Trypanosoma cruzi in rhesus macaques

Background: Chronic Chagasic cardiomyopathy is responsible for a large disease burden in the Americas, and a therapeutic vaccine would be highly desirable. We tested the safety and efficacy of a therapeutic DNA vaccine encoding antigens TSA-1 and Tc24 for preventing cardiac alterations in experiment...

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Autors principals:	Eric Dumonteil, Claudia Herrera, Preston A. Marx
Format:	Artigo
Idioma:	Inglês
Publicat:	Elsevier 2023-04-01
Col·lecció:	Journal of Microbiology, Immunology and Infection
Matèries:	Chagas disease DNA vaccine Cardiomyopathy Non-human primates Electrocardiograph
Accés en línia:	http://www.sciencedirect.com/science/article/pii/S1684118222001542
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