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An optogenetic cell therapy to restore control of target muscles in an aggressive mouse model of amyotrophic lateral sclerosis

Breakdown of neuromuscular junctions (NMJs) is an early pathological hallmark of amyotrophic lateral sclerosis (ALS) that blocks neuromuscular transmission, leading to muscle weakness, paralysis and, ultimately, premature death. Currently, no therapies exist that can prevent progressive motor neuron...

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Principais autores: J Barney Bryson, Alexandra Kourgiantaki, Dai Jiang, Andreas Demosthenous, Linda Greensmith
Format: Artigo
Sprog:Inglês
Udgivet: eLife Sciences Publications Ltd 2024-01-01
Serier:eLife
Fag:
regenerative medicine
motor neurons
optogenetics
Amyotrophic Lateral Sclerosis
paralysis
cell transplant
Online adgang:https://elifesciences.org/articles/88250
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