Neural basis for mutant ATAXIN-1 induced respiratory dysfunction in mouse models of spinocerebellar ataxia type 1

Spinocerebellar ataxia type 1 is a neurodegenerative disease characterized by motor dysfunction and premature death usually from compromised swallowing and respiration. Using plethysmography, we characterized respiration in the conditional f-ATXN1146Q/2Q SCA1 model. We found a progressive elevation...

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Bibliographic Details

Main Authors:	Alyssa Soles, Jessica Grittner, Kaia Douglas, Praseuth Yang, Lisa Duvick, Brennon O'Callaghan, Ryan Barnett, Christine Chau, Roj Cosiquien, Orion Rainwater, Shannah Serres, Brendan Dougherty, Harry T. Orr, Marija Cvetanovic
Format:	Artigo
Language:	Inglês
Published:	Elsevier 2026-05-01
Series:	Neurobiology of Disease
Subjects:	SCA1 ATXN1 Breathing dysfunction Bulbar dysfunction
Online Access:	http://www.sciencedirect.com/science/article/pii/S0969996126001014
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