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Targeting light-gated chloride channels to neuronal somatodendritic domain reduces their excitatory effect in the axon

Light-gated chloride channels are emerging as promising optogenetic tools for inhibition of neural activity. However, their effects depend on the transmembrane chloride electrochemical gradient and may be complex due to the heterogeneity of this gradient in different developmental stages, neuronal t...

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Hlavní autoři: Jessica E Messier, Hongmei Chen, Zhao-Lin Cai, Mingshan Xue
Médium: Artigo
Jazyk:Inglês
Vydáno: eLife Sciences Publications Ltd 2018-08-01
Edice:eLife
Témata:
On-line přístup:https://elifesciences.org/articles/38506
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