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Effect of the genetic mutant G71R in uridine diphosphate-glucuronosyltransferase 1A1 on the conjugation of bilirubin

We aimed to investigate the effect of the genetic mutant G71R (c. 211G > A) in uridine diphosphate (UDP)-glucuronosyltransferase 1A1 (UGT1A1) on the glucuronidation of unconjugated bilirubin. The UGT1A1 wild-type and mutant G71R gene sequences were inserted into the lentiviral vector GV358 plasmid a...

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Principais autores: Chen Hong, Zhong Danni, Gao Zongyan, Wu Xiaojing
Format: Artigo
Sprog:Inglês
Udgivet: De Gruyter 2022-03-01
Serier:Open Life Sciences
Fag:
lentiviral vector
g71r mutant
hyperbilirubinemia
udp-glucuronosyltransferase 1a1
Online adgang:https://doi.org/10.1515/biol-2022-0021
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