The expression landscape and heterogeneity of nectin-4, HER2, and Trop-2 in urothelial carcinoma: clinicopathological correlations and implications for ADC-guided precision therapy

BackgroundAntibody-drug conjugates (ADCs) have redefined the treatment of urothelial carcinoma (UC). However, the spatiotemporal heterogeneity and co-expression landscapes of these targets across diverse anatomical sites and pathological stages remain poorly understood. This study aimed to map these...

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Autori principali:	Shaobo Qin, Zhicheng Dai, Zhenxing Hu, Xiaohui Wang, Huiyan Zhang, Haotian Yang, Jie Liu, Lianghong Ma
Natura:	Artigo
Lingua:	Inglês
Pubblicazione:	Frontiers Media S.A. 2026-07-01
Serie:	Frontiers in Oncology
Soggetti:	antibody-drug conjugates co-expression HER2 heterogeneity nectin-4 Trop-2
Accesso online:	https://www.frontiersin.org/articles/10.3389/fonc.2026.1887794/full
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