Investigating the molecular basis of Siah1 and Siah2 E3 ubiquitin ligase substrate specificity.
The Siah1 and Siah2 E3 ubiquitin ligases play an important role in diverse signaling pathways and have been shown to be deregulated in cancer. The human Siah1 and Siah2 isoforms share high sequence similarity but possess contrary roles in cancer, with Siah1 more often acting as a tumor suppressor wh...
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| Автори: | , , |
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| Формат: | Artigo |
| Мова: | Inglês |
| Опубліковано: |
Public Library of Science (PLoS)
2014-01-01
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| Серія: | PLoS ONE |
| Онлайн доступ: | http://europepmc.org/articles/PMC4159269?pdf=render |
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