Clustered CTCF binding is an evolutionary mechanism to maintain topologically associating domains

Abstract Background CTCF binding contributes to the establishment of a higher-order genome structure by demarcating the boundaries of large-scale topologically associating domains (TADs). However, despite the importance and conservation of TADs, the role of CTCF binding in their evolution and stabil...

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Библиографические подробности

Главные авторы:	Elissavet Kentepozidou, Sarah J. Aitken, Christine Feig, Klara Stefflova, Ximena Ibarra-Soria, Duncan T. Odom, Maša Roller, Paul Flicek
Формат:	Artigo
Язык:	Inglês
Опубликовано:	BMC 2020-01-01
Серии:	Genome Biology
Предметы:	CTCF binding evolution Chromatin architecture TADs Cross-species analysis
Online-ссылка:	https://doi.org/10.1186/s13059-019-1894-x
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