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Characterization of niphatenones that inhibit androgen receptor N-terminal domain.

Androgen ablation therapy causes a temporary reduction in tumor burden in patients with advanced prostate cancer. Unfortunately the malignancy will return to form lethal castration-recurrent prostate cancer (CRPC). The androgen receptor (AR) remains transcriptionally active in CRPC in spite of castr...

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Principais autores: Carmen A Banuelos, Aaron Lal, Amy H Tien, Neel Shah, Yu Chi Yang, Nasrin R Mawji, Labros G Meimetis, Jacob Park, Jian Kunzhong, Raymond J Andersen, Marianne D Sadar
Format: Artigo
Sprog:Inglês
Udgivet: Public Library of Science (PLoS) 2014-01-01
Serier:PLoS ONE
Online adgang:http://europepmc.org/articles/PMC4182434?pdf=render
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