Impaired immune response mediated by prostaglandin E2 promotes severe COVID-19 disease.

The SARS-CoV-2 coronavirus has led to a pandemic with millions of people affected. The present study finds that risk-factors for severe COVID-19 disease courses, i.e. male sex, older age and sedentary life style are associated with higher prostaglandin E2 (PGE2) serum levels in blood samples from un...

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Autors principals:	Melanie Ricke-Hoch, Elisabeth Stelling, Lisa Lasswitz, Antonia P Gunesch, Martina Kasten, Francisco J Zapatero-Belinchón, Graham Brogden, Gisa Gerold, Thomas Pietschmann, Virginie Montiel, Jean-Luc Balligand, Federica Facciotti, Emilio Hirsch, Thomas Gausepohl, Husni Elbahesh, Guus F Rimmelzwaan, Anne Höfer, Mark P Kühnel, Danny Jonigk, Julian Eigendorf, Uwe Tegtbur, Lena Mink, Michaela Scherr, Thomas Illig, Axel Schambach, Tobias J Pfeffer, Andres Hilfiker, Axel Haverich, Denise Hilfiker-Kleiner
Format:	Artigo
Idioma:	Inglês
Publicat:	Public Library of Science (PLoS) 2021-01-01
Col·lecció:	PLoS ONE
Accés en línia:	https://doi.org/10.1371/journal.pone.0255335
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