Targeting MYC dependency in ovarian cancer through inhibition of CDK7 and CDK12/13

High-grade serous ovarian cancer is characterized by extensive copy number alterations, among which the amplification of MYC oncogene occurs in nearly half of tumors. We demonstrate that ovarian cancer cells highly depend on MYC for maintaining their oncogenic growth, indicating MYC as a therapeutic...

Descripció completa

Dades bibliogràfiques

Autors principals:	Mei Zeng, Nicholas P Kwiatkowski, Tinghu Zhang, Behnam Nabet, Mousheng Xu, Yanke Liang, Chunshan Quan, Jinhua Wang, Mingfeng Hao, Sangeetha Palakurthi, Shan Zhou, Qing Zeng, Paul T Kirschmeier, Khyati Meghani, Alan L Leggett, Jun Qi, Geoffrey I Shapiro, Joyce F Liu, Ursula A Matulonis, Charles Y Lin, Panagiotis A Konstantinopoulos, Nathanael S Gray
Format:	Artigo
Idioma:	Inglês
Publicat:	eLife Sciences Publications Ltd 2018-11-01
Col·lecció:	eLife
Matèries:	ovarian cancer MYC THZ1 CDK7 CDK12/13 MCL-1
Accés en línia:	https://elifesciences.org/articles/39030
Etiquetes:	Afegir etiqueta Sense etiquetes, Sigues el primer a etiquetar aquest registre!