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SFXN1 expression analysis in oral squamous cell carcinoma and its association with the PI3K-AKT-mTOR pathway and immune cell infiltration

Background: Oral squamous cell carcinoma (OSCC) is a predominant malignancy characterized by aggressive progression and poor prognosis. This study investigated the role of SFXN1 (Sideroflexin 1), a mitochondrial serine transporter, in OSCC using integrated bioinformatic and experimental approaches....

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Principais autores: Prabhu Manickam Natarajan, Manoj Kumar Karuppan Perumal, Sudhir Rama Varma, Sam Thomas Kuriadom, Ruba Odeh, Remya Rajan Renuka
Formato: Artigo
Idioma:Inglês
Publicado em: Elsevier 2026-01-01
coleção:Journal of Oral Biology and Craniofacial Research
Assuntos:
SFXN1
OSCC
PI3K-AKT-mTOR
Immune infiltration
Biomarker
Bioinformatics
Acesso em linha:http://www.sciencedirect.com/science/article/pii/S2212426825002817
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