Succinate–GPR91 signaling promotes cardiomyocyte metabolic reprogramming and NAD+ production to alleviate HFpEF
Abstract Background Disrupted cardiomyocyte energy metabolism is a hallmark of heart failure with preserved ejection fraction (HFpEF). Succinate, a key intermediate of the tricarboxylic acid cycle, is markedly decreased in HFpEF myocardium. In addition to its metabolic role, succinate functions as a...
Sparad:
| Huvudupphov: | , , , , , , , |
|---|---|
| Materialtyp: | Artigo |
| Språk: | Inglês |
| Utgiven: |
BMC
2025-12-01
|
| Serie: | Cardiovascular Diabetology |
| Ämnen: | |
| Länkar: | https://doi.org/10.1186/s12933-025-03030-x |
| Taggar: |
Inga taggar, Lägg till första taggen!
|