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Modulation of Metabotropic Glutamate Receptors as a Strategy to Improve the Efficacy and Safety of Ketamine as an Antidepressant

Since the introduction of the NMDA receptor antagonist (<i>S</i>)-ketamine for depression therapy, it has become evident that the glutamatergic hypothesis of depression, proposed over 20 years ago, was justified and based on solid foundations. A significant breakthrough with this drug is its ability...

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Autor Principal: Agnieszka Pałucha-Poniewiera
Formato: Artigo
Idioma:Inglês
Publicado: MDPI AG 2025-12-01
Series:Cells
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Acceso en liña:https://www.mdpi.com/2073-4409/14/24/1967
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