Allele-Level KIR Genotyping of More Than a Million Samples: Workflow, Algorithm, and Observations

The killer-cell immunoglobulin-like receptor (KIR) genes regulate natural killer cell activity, influencing predisposition to immune mediated disease, and affecting hematopoietic stem cell transplantation (HSCT) outcome. Owing to the complexity of the KIR locus, with extensive gene copy number varia...

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Egile Nagusiak:	Ines Wagner, Daniel Schefzyk, Jens Pruschke, Gerhard Schöfl, Bianca Schöne, Nicole Gruber, Kathrin Lang, Jan Hofmann, Christine Gnahm, Bianca Heyn, Wesley M. Marin, Ravi Dandekar, Jill A. Hollenbach, Johannes Schetelig, Julia Pingel, Paul J. Norman, Jürgen Sauter, Alexander H. Schmidt, Vinzenz Lange
Formatua:	Artigo
Hizkuntza:	Inglês
Argitaratua:	Frontiers Media S.A. 2018-12-01
Saila:	Frontiers in Immunology
Gaiak:	next generation sequencing NGS KIR genotyping KIR killer cell immunoglobulin-like receptors allele-level resolution
Sarrera elektronikoa:	https://www.frontiersin.org/article/10.3389/fimmu.2018.02843/full
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