Combination Ad26.RSV.preF/preF protein vaccine induces superior protective immunity compared with individual vaccine components in preclinical models

Abstract Respiratory syncytial virus (RSV) is a leading cause of severe respiratory disease for which no licensed vaccine is available. We have previously shown that a prefusion (preF) conformation-stabilized RSV F protein antigen and an adenoviral vector encoding RSV preF protein (Ad26.RSV.preF) ar...

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Principais autores:	Eirikur Saeland, Leslie van der Fits, Renske Bolder, Marjolein Heemskerk-van der Meer, Joke Drijver, Yolinda van Polanen, Cornelis Vaneman, Lisanne Tettero, Freek Cox, Jan Serroyen, Matthew J. Jorgensen, Johannes P. M. Langedijk, Hanneke Schuitemaker, Benoit Callendret, Roland C. Zahn
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Nature Portfolio 2023-03-01
coleção:	npj Vaccines
Acesso em linha:	https://doi.org/10.1038/s41541-023-00637-7
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