Loss of mTOR repressors Tsc1 or Pten has divergent effects on excitatory and inhibitory synaptic transmission in single hippocampal neuron cultures.
The Pten and Tsc1 genes both encode proteins that repress mechanistic target of rapamycin (mTOR) signaling. Disruption of either gene in the brain results in epilepsy and autism-like symptoms in humans and mouse models, therefore it is important to understand the molecular and physiological events t...
Sparad:
| Huvudupphov: | , , |
|---|---|
| Materialtyp: | Artigo |
| Språk: | Inglês |
| Utgiven: |
Frontiers Media S.A.
2014-02-01
|
| Serie: | Frontiers in Molecular Neuroscience |
| Ämnen: | |
| Länkar: | http://journal.frontiersin.org/Journal/10.3389/fnmol.2014.00001/full |
| Taggar: |
Inga taggar, Lägg till första taggen!
|