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Identification of a novel NRF1::PDGFRA fusion in myeloid/lymphoid neoplasms with eosinophilia and tyrosine kinase gene fusions

A novel fusion gene NRF1::PDGFRA was identified in a patient with myeloid/lymphoid neoplasms with eosinophilia and tyrosine kinase gene fusions (MLN-TK), harboring the chromosome abnormality t(4;7)(q12;q32). This represents the first reported case of the NRF1::PDGFRA fusion gene, and the ninth PDGFR...

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Principais autores: Jialong Liu, Yaqing Feng, Yanfang Zhang, Yingnan Xiao, Xi Liu, Tingting Xiao, Junyan Zou, Kai Fan, Lisha Lu, Xiaoxia Yang, Jinying Gong
Format: Artigo
Sprog:Inglês
Udgivet: Frontiers Media S.A. 2025-03-01
Serier:Frontiers in Oncology
Fag:
eosinophilia
PDGFRA rearrangement
NRF1
MLN-TK
gene fusion
imatinib
Online adgang:https://www.frontiersin.org/articles/10.3389/fonc.2025.1552928/full
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