PA28αβ: The Enigmatic Magic Ring of the Proteasome?

PA28αβ is a γ-interferon-induced 11S complex that associates with the ends of the 20S proteasome and stimulates in vitro breakdown of small peptide substrates, but not proteins or ubiquitin-conjugated proteins. In cells, PA28 also exists in larger complexes along with the 19S particle, which allows...

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Bibliographic Details

Main Author:	Paolo Cascio
Format:	Artigo
Language:	Inglês
Published:	MDPI AG 2014-06-01
Series:	Biomolecules
Subjects:	PA28αβ proteasomes immunoproteasomes protein degradation MHC class I antigen presentation epitopes antigenic peptides
Online Access:	http://www.mdpi.com/2218-273X/4/2/566
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