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The proteostatic landscape of healthy human oocytes

Abstract Oocytes, female germ cells that develop into eggs, are among the longest-lived cells in the animal body. Recent studies on mouse oocytes highlight unique adaptations in protein homeostasis (proteostasis) within these cells. However, the mechanisms of proteostasis in human oocytes remain vir...

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Principais autores: Gabriele Zaffagnini, Miquel Solé, Juan Manuel Duran, Nikolaos P Polyzos, Elvan Böke
Format: Artigo
Sprog:Inglês
Udgivet: Springer Nature 2025-07-01
Serier:The EMBO Journal
Fag:
Female Fertility
Human Oocytes
Proteostasis
Lysosomes
Mitochondria
Online adgang:https://doi.org/10.1038/s44318-025-00493-2
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