DGAT1 deficiency decreases PPAR expression and does not lead to lipotoxicity in cardiac and skeletal muscle[S]

Diacylglycerol (DAG) acyl transferase 1 (Dgat1) knockout (−/−) mice are resistant to high-fat-induced obesity and insulin resistance, but the reasons are unclear. Dgat1−/− mice had reduced mRNA levels of all three Ppar genes and genes involved in fatty acid oxidation in the myocardium of Dgat1−/− mi...

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Detalhes bibliográficos

Principais autores:	Li Liu, Shuiqing Yu, Raffay S. Khan, Gene P. Ables, Kalyani G. Bharadwaj, Yunying Hu, Lesley A. Huggins, Jan W. Eriksson, Linda K. Buckett, Andrew V. Turnbull, Henry N. Ginsberg, William S. Blaner, Li-Shin Huang, Ira J. Goldberg
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Elsevier 2011-04-01
coleção:	Journal of Lipid Research
Assuntos:	heart triglyceride diacylglycerol acyl transferase ceramide exercise muscle hypertrophy
Acesso em linha:	http://www.sciencedirect.com/science/article/pii/S0022227520409071
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