Targeting heparan sulfate proteoglycans as an effective strategy for inhibiting cancer cell migration and invasiveness compared to heparin

By virtue of their ability to bind different growth factors, morphogens and extracellular matrix proteins, heparan sulfate proteoglycans (HSPGs) play a determinant role in cancer cell differentiation and migration. Despite a strong conceptual basis and promising preclinical results, clinical trials...

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Principais autores:	Lorenzo Depau, Jlenia Brunetti, Chiara Falciani, Elisabetta Mandarini, Marta Zanchi, Maria Francesca Paolocci, Marta Garfì, Alessandro Pini, Luisa Bracci
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Frontiers Media S.A. 2025-01-01
coleção:	Frontiers in Cell and Developmental Biology
Assuntos:	heparan sulfate proteoglycans cancer cell migration peptide extracellular matrix tumor target
Acesso em linha:	https://www.frontiersin.org/articles/10.3389/fcell.2024.1505680/full
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