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Multi-level evidence reveals PANK2 as a potential target of PFOA/PFOS-induced bone metabolism disruption: From network toxicology to in vitro validation

Perfluorooctanoic acid (PFOA) and perfluorooctanesulfonic acid (PFOS) are two representative per- and polyfluoroalkyl substances (PFAS) that have attracted increasing attention due to their environmental persistence and potential health risks, while their bone toxicity remains unclear. In this study...

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Principais autores: Yiming Shao, Wenhao Fan
Format: Artigo
Sprog:Inglês
Udgivet: Elsevier 2025-09-01
Serier:Ecotoxicology and Environmental Safety
Fag:
PFOA
PFOS
Osteoporosis
PANK2
Network toxicology
Molecular docking
Online adgang:http://www.sciencedirect.com/science/article/pii/S0147651325009388
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