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Spermidine prevents iron overload-induced impaired bone mass by activating SIRT1/SOD2 signaling in senile rat model

Spermidine (SPD) is an organic compound known for its powerful antioxidant stress and anti-aging properties, and whether SPD has the ability to reduce bone mass in elderly iron overload rats is unknown. The study aimed to assess SPD's impact on iron overload-induced bone loss in elderly rats. In our...

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Principais autores: Zhi-Qing Du, Jia-Bin Xie, Sheng-Yi Ji, Wanshu Zhou, Zhou-Shan Tao
Formato: Artigo
Idioma:Inglês
Publicado em: Taylor & Francis Group 2025-12-01
coleção:Redox Report
Assuntos:
Iron overload
oxidative stress
spermidine
bone mass
bone metabolism
senile osteoporosis
Acesso em linha:https://www.tandfonline.com/doi/10.1080/13510002.2025.2485666
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