Myeloid-specific deletion of autotaxin inhibits rheumatoid arthritis and osteoclastogenesis

Rheumatoid arthritis (RA) is a chronic autoimmune disease characterized by joint swelling, pain, and bone remodeling. We previously reported that autotaxin (ATX) deficiency disrupts lipid rafts in macrophages. Lipid raft disruption results in the dysregulation of RANK signaling, which is crucial for...

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Principais autores:	Gwangbeom Heo, Sihyun Jeong, Soyeong Park, Su Jin Kim, Yunna Lee, Seong Ji Woo, Kyunghwan Kim, Byung-Hyun Park, Sang Hoon Rhee, Eunok Im
格式:	Artigo
語言:	Inglês
出版:	Frontiers Media S.A. 2024-12-01
叢編:	Frontiers in Immunology
主題:	rheumatoid arthritis autotaxin lipid rafts osteoclastogenesis collagen-induced arthritis
在線閱讀:	https://www.frontiersin.org/articles/10.3389/fimmu.2024.1481699/full
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