The mechanism of glycosphingolipid degradation revealed by a GALC-SapA complex structure

Lysosomal degradation of sphingolipids requires lipid-binding saposin proteins and hydrolytic enzymes. Here the authors present the crystal structure of the hydrolase β-galactocerebrosidase in complex with saposin SapA and give insights into the glycosphingolipid galactocerebroside degradation mecha...

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Autors principals:	Chris H. Hill, Georgia M. Cook, Samantha J. Spratley, Stuart Fawke, Stephen C. Graham, Janet E. Deane
Format:	Artigo
Idioma:	Inglês
Publicat:	Nature Portfolio 2018-01-01
Col·lecció:	Nature Communications
Accés en línia:	https://doi.org/10.1038/s41467-017-02361-y
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