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BacMam virus-based surface display for HCV E2 glycoprotein induces strong cross-neutralizing antibodies and cellular immune responses in vaccinated mice

Abstract Background Despite recent advancements, limitations in the treatment and control of hepatitis C virus (HCV) infection reprioritized the studies for invention of an efficient HCV vaccine to elicit strong neutralizing antibodies (NAbs) and cellular responses. Methods Herein, we report molecul...

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Principais autores: Ebrahim Kord, Farzin Roohvand, Jean Dubuisson, Thibaut Vausselin, Hosein Nasr Azadani, Abolfazl Keshavarz, Ahmad Nejati, Katayoun Samimi-Rad
Format: Artigo
Sprog:Inglês
Udgivet: BMC 2021-12-01
Serier:Infectious Agents and Cancer
Fag:
HCV
gpE2
Baculovirus
BacMam virus
Surface display
Vaccine
Online adgang:https://doi.org/10.1186/s13027-021-00407-x
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