“Superwobbling” and tRNA-34 Wobble and tRNA-37 Anticodon Loop Modifications in Evolution and Devolution of the Genetic Code

The genetic code evolved around the reading of the tRNA anticodon on the primitive ribosome, and tRNA-34 wobble and tRNA-37 modifications coevolved with the code. We posit that EF-Tu, the closing mechanism of the 30S ribosomal subunit, methylation of wobble U34 at the 5-carbon and suppression of wob...

Ausführliche Beschreibung

Bibliografische Detailangaben

Hauptverfasser:	Lei Lei, Zachary Frome Burton
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	MDPI AG 2022-02-01
Schriftenreihe:	Life
Schlagworte:	elongation factor Tu evolution of the genetic code four-way wobbling genetic code degeneracy inosine mitochondria
Online-Zugang:	https://www.mdpi.com/2075-1729/12/2/252
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