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Early inflammation as a footprint of increased mortality risk in infants living with HIV from three African countries

Abstract In this work our aim was to identify early biomarkers in plasma samples associated with mortality in children with perinatal HIV treated early in life, to potentially inform early intervention targeting this vulnerable group. 20/215 children (9.3%) with perinatal HIV, enrolled within 3 mont...

Ausführliche Beschreibung

Gespeichert in:
Hauptverfasser: Elena Morrocchi, Giuseppe R. Pascucci, Nicola Cotugno, Chiara Pighi, Sara Dominguez-Rodriguez, Maria Raffaella Petrara, Alfredo Tagarro, Louise Kuhn, Mark F. Cotton, Kennedy Otwombe, Maria G. Lain, Paula Vaz, Shaun L. Barnabas, Moira J. Spyer, Elisa Lopez, Sheila Fernández-Luis, Tacilta Nhampossa, Almoustapha I. Maiga, Oumar Dolo, Anita De Rossi, Pablo Rojo, Carlo Giaquinto, Mathias Lichterfeld, Avy Violari, Theresa Smit, Osee Behuhuma, Nigel Klein, Lesley De Armas, Savita Pahwa, Paolo Rossi, Paolo Palma, EPIICAL consortium
Format: Artigo
Sprache:Inglês
Veröffentlicht: Nature Portfolio 2024-10-01
Schriftenreihe:Scientific Reports
Schlagworte:
Predictive model
Inflammatory biomarkers
IL-6
Pediatric population
HIV infection
PAMPs and DAMPs
Online-Zugang:https://doi.org/10.1038/s41598-024-74066-4
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