Intestinal mucosal alterations parallel central demyelination and remyelination: insights into the gut-brain axis in the cuprizone model of multiple sclerosis

BackgroundThe gut-brain axis has been increasingly recognized as a critical factor in Multiple Sclerosis (MS) pathophysiology. While its role in demyelination is well documented, gut-brain axis involvement during remyelination remains largely unexplored.MethodsUsing the cuprizone (CPZ) model, which...

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Principais autores:	Carolina Ferreira, Filipa Carvalho, Pedro Vieira, André Alves, Filipe Palavra, Jani Almeida, Vera Alves, Ezequiel Coscueta, Patrícia Dias Pereira, Manuela Pintado, Helena Sá, Miguel Castelo-Branco, Flávio Reis, Sofia Viana
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Frontiers Media S.A. 2025-10-01
coleção:	Frontiers in Immunology
Assuntos:	cuprizone-induced demyelination remyelination gut-brain axis gut microbiota intestinal innate and adaptative immunity multiple sclerosis
Acesso em linha:	https://www.frontiersin.org/articles/10.3389/fimmu.2025.1682183/full
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