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Doxycycline attenuates l-DOPA-induced dyskinesia through an anti-inflammatory effect in a hemiparkinsonian mouse model

The pharmacological manipulation of neuroinflammation appears to be a promising strategy to alleviate l-DOPA-induced dyskinesia (LID) in Parkinson’s disease (PD). Doxycycline (Doxy), a semisynthetic brain-penetrant tetracycline antibiotic having interesting anti-inflammatory properties, we addressed...

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Principais autores: Maurício dos Santos Pereira, Glauce Crivelaro do Nascimento, Mariza Bortolanza, Patrick Pierre Michel, Rita Raisman-Vozari, Elaine Del Bel
Format: Artigo
Sprog:Inglês
Udgivet: Frontiers Media S.A. 2022-11-01
Serier:Frontiers in Pharmacology
Fag:
neuroinflammation
cytokines
tetracyclines
Parkinson’s disease
IL-1β
TNF-α
Online adgang:https://www.frontiersin.org/articles/10.3389/fphar.2022.1045465/full
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