Immunogenicity of COVID-eVax Delivered by Electroporation Is Moderately Impacted by Temperature and Molecular Isoforms

DNA integrity is a key issue in gene therapy and genetic vaccine approaches based on plasmid DNA. In contrast to messenger RNA that requires a controlled cold chain for efficacy, DNA molecules are considered to be more stable. In this study, we challenged this concept by characterizing the immunolog...

Ausführliche Beschreibung

Bibliografische Detailangaben

Hauptverfasser:	Federico D’Alessio, Lucia Lione, Erika Salvatori, Federica Bucci, Alessia Muzi, Giuseppe Roscilli, Mirco Compagnone, Eleonora Pinto, Gianfranco Battistuzzi, Antonella Conforti, Luigi Aurisicchio, Fabio Palombo
Format:	Artigo
Sprache:	Inglês
Veröffentlicht:	MDPI AG 2023-03-01
Schriftenreihe:	Vaccines
Schlagworte:	COVID-19 DNA stability immune responses vaccines
Online-Zugang:	https://www.mdpi.com/2076-393X/11/3/678
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