Metabolomic profiling identifies distinct phenotypes for ASS1 positive and negative GBM

Abstract Background Tumour cells have a high demand for arginine. However, a subset of glioblastomas has a defect in the arginine biosynthetic pathway due to epigenetic silencing of the rate limiting enzyme argininosuccinate synthetase (ASS1). These tumours are auxotrophic for arginine and susceptib...

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Hlavní autoři:	Lina Mörén, Richard Perryman, Tim Crook, Julia K. Langer, Kevin Oneill, Nelofer Syed, Henrik Antti
Médium:	Artigo
Jazyk:	Inglês
Vydáno:	BMC 2018-02-01
Edice:	BMC Cancer
Témata:	Glioblastoma Epigenetics ASS1 Arginine ADI-PEG20 Metabolomics
On-line přístup:	http://link.springer.com/article/10.1186/s12885-018-4040-3
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