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mRNA delivery of circumsporozoite protein epitope-based malaria vaccines induces protection in a mouse model

Abstract Malaria is a leading cause of disease in developing countries. The licensed malaria vaccines (RTS,S/AS01 and R21/Matrix-M) have shown significant efficacy in human phase 3 trials. Vaccination with radiation-attenuated sporozoites has achieved high levels of protection against malaria in con...

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Principais autores: Nelson R. Wu, Nathan Beutler, Xiaozhen Hu, Patrick D. Skog, Alessia Liguori, Yevel Flores-Garcia, Laura Maiorino, Sierra Terada, Danny Lu, Yen-Chung Lai, Justin Ndihokubwayo, Torben Schiffner, Christopher A. Cottrell, Saman Eskandarzadeh, Nushin Alavi, Michael Kubitz, Nicole Phelps, Ryan Tingle, Sam Hodges, John E. Youhanna, Sonya Amirzehni, Darrell J. Irvine, Sunny Himansu, Fidel Zavala, Thomas F. Rogers, Dennis R. Burton, William R. Schief
Formato: Artigo
Idioma:Inglês
Publicado em: Nature Portfolio 2025-11-01
coleção:npj Vaccines
Acesso em linha:https://doi.org/10.1038/s41541-025-01296-6
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