Immune checkpoint blockade induced shifts in cytokine expression patterns in peripheral blood of head and neck cancer patients are linked to outcome

BackgroundImmune-checkpoint blockade (ICB) of programmed-death-1 (PD-1) with pembrolizumab or nivolumab is approved for treating recurrent/metastatic (R/M) head and neck squamous cell carcinoma (HNSCC). NadiHN and ADRISK are phase IIB trials investigating in locally advanced (LA) HNSCC having low or...

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Hlavní autoři:	Louisa Röhl, Jana Wellhausen, Michael Berszin, Irene Krücken, Veit Zebralla, Markus Pirlich, Susanne Wiegand, Andreas Dietz, Theresa Wald, Gunnar Wichmann
Médium:	Artigo
Jazyk:	Inglês
Vydáno:	Frontiers Media S.A. 2023-10-01
Edice:	Frontiers in Immunology
Témata:	immune checkpoint inhibitor-blockade (ICB) programmed-death 1 (PD-1) head and neck squamous cell carcinoma (HNSCC) liquid biopsy cytokine expression pattern (CEP) interferon gamma (IFN-γ)
On-line přístup:	https://www.frontiersin.org/articles/10.3389/fimmu.2023.1237623/full
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