Chemokine CCL2 prevents opioid-induced inhibition of nociceptive synaptic transmission in spinal cord dorsal horn

Abstract Background Opioid analgesics remain widely used for pain treatment despite the related serious side effects. Some of those, such as opioid tolerance and opioid-induced hyperalgesia may be at least partially due to modulation of opioid receptors (OR) function at nociceptive synapses in the s...

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Principais autores:	Mario Heles, Petra Mrozkova, Dominika Sulcova, Pavel Adamek, Diana Spicarova, Jiri Palecek
Formato:	Artigo
Idioma:	Inglês
Publicado:	BMC 2021-12-01
Series:	Journal of Neuroinflammation
Assuntos:	CCL2 TRPV1 MOR Microglia Synaptic transmission Spinal cord
Acceso en liña:	https://doi.org/10.1186/s12974-021-02335-4
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