Mechanism of action of 2-aminobenzamide HDAC inhibitors in reversing gene silencing in Friedreich’s ataxia

The genetic defect in Friedreich’s ataxia (FRDA) is the hyperexpansion of a GAA•TTC triplet in the first intron of the FXN gene, encoding the essential mitochondrial protein frataxin. Histone posttranslational modifications near the expanded repeats are consistent with heterochromatin formation and...

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Prif Awduron:	Elisabetta eSoragni, C. James Chou, James R. Rusche, Joel M. Gottesfeld
Fformat:	Artigo
Iaith:	Inglês
Cyhoeddwyd:	Frontiers Media S.A. 2015-03-01
Cyfres:	Frontiers in Neurology
Pynciau:	epigenetics Histone deacetylase inhibitor frataxin Friedreich’s ataxia 2-Aminobenzamide
Mynediad Ar-lein:	http://journal.frontiersin.org/Journal/10.3389/fneur.2015.00044/full
Tagiau:	Ychwanegu Tag Dim Tagiau, Byddwch y cyntaf i dagio'r cofnod hwn!