The gut microbiome as an actionable drug-sensitivity modulator for immune checkpoint blockade: clinical evidence for FMT, live biotherapeutics, and defined consortia

Immune checkpoint inhibitors (ICIs) deliver durable benefit to only a subset of patients and can be limited by immune-related adverse events (irAEs). The gut microbiome has emerged as an actionable, host-level modulator of ICI drug sensitivity and toxicity. This mini-review links microbial ecology t...

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Detalhes bibliográficos

Principais autores:	Wenqian Han, Quanfang Li, Guangwen Yuan
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Frontiers Media S.A. 2026-03-01
coleção:	Frontiers in Immunology
Assuntos:	fecal microbiota transplantation gut microbiome immune checkpoint inhibitors live biotherapeutic products microbiome engineering
Acesso em linha:	https://www.frontiersin.org/articles/10.3389/fimmu.2026.1802676/full
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