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Biopharmaceutical Assessment of Dexamethasone Acetate-Based Hydrogels Combining Hydroxypropyl Cyclodextrins and Polysaccharides for Ocular Delivery

We previously developed two optimized formulations of dexamethasone acetate (DXMa) hydrogels by means of special cubic mixture designs for topical ocular administration. These gels were elaborated with hydroxypropyl-β-CD (HPβCD) and hydroxypropyl-γ-CD (HPγCD) and commercial hydrogels in order to enh...

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Principais autores: Roseline Mazet, Xurxo García-Otero, Luc Choisnard, Denis Wouessidjewe, Vincent Verdoot, Frédéric Bossard, Victoria Díaz-Tomé, Véronique Blanc-Marquis, Francisco-Javier Otero-Espinar, Anxo Fernandez-Ferreiro, Annabelle Gèze
Format: Artigo
Sprog:Inglês
Udgivet: MDPI AG 2020-07-01
Serier:Pharmaceutics
Fag:
dexamethasone acetate
cyclodextrins
eye drops
hydrogels
rheology
cytotoxicity studies
Online adgang:https://www.mdpi.com/1999-4923/12/8/717
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