Transmembrane domain switching controls PINK1 import and fate in mitochondria
Abstract Mitochondrial targeting of the PINK1 kinase results, under normal conditions, in membrane-potential-driven inner membrane penetration and cleavage by the resident protease PARL before retro-translocation and proteasomal degradation. In compromised mitochondria, with reduced membrane potenti...
Gardado en:
| Principais autores: | , , , , |
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| Formato: | Artigo |
| Idioma: | Inglês |
| Publicado: |
Springer Nature
2026-05-01
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| Series: | The EMBO Journal |
| Acceso en liña: | https://doi.org/10.1038/s44318-026-00789-x |
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