The Escherichia coli alkA Gene Is Activated to Alleviate Mutagenesis by an Oxidized Deoxynucleoside

The cellular methyl donor S-adenosylmethionine (SAM) and other endo/exogenous agents methylate DNA bases non-enzymatically into products interfering with replication and transcription. An important product is 3-methyladenine (m3A), which in Escherichia coli is removed by m3A-DNA glycosylase I (Tag)...

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Autors principals:	Kristin Grøsvik, Almaz Nigatu Tesfahun, Izaskun Muruzábal-Lecumberri, Gyri Teien Haugland, Ingar Leiros, Peter Ruoff, Jan Terje Kvaløy, Ingeborg Knævelsrud, Hilde Ånensen, Marina Alexeeva, Kousuke Sato, Akira Matsuda, Ingrun Alseth, Arne Klungland, Svein Bjelland
Format:	Artigo
Idioma:	Inglês
Publicat:	Frontiers Media S.A. 2020-02-01
Col·lecció:	Frontiers in Microbiology
Matèries:	5-formyluracil oxidized base repair base substitution AlkA DNA glycosylase
Accés en línia:	https://www.frontiersin.org/article/10.3389/fmicb.2020.00263/full
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