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Identification of giant Mimivirus protein functions using RNA interference

Genomic analysis of giant viruses, such as Mimivirus, has revealed that more than half of the putative genes have no known functions (ORFans). We knocked down Mimivirus genes using short interfering RNA (siRNA) as a proof of concept to determine the functions of giant virus ORFans. As fibers are eas...

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Principais autores: Haitham eSobhy, Bernard eLa Scola, Isabelle ePagnier, Didier eRaoult, Philippe eColson
Formato: Artigo
Idioma:Inglês
Publicado em: Frontiers Media S.A. 2015-04-01
coleção:Frontiers in Microbiology
Assuntos:
RNA Interference
Fiber
Mimivirus
giant virus
Megavirales
short interfering RNA
Acesso em linha:http://journal.frontiersin.org/Journal/10.3389/fmicb.2015.00345/full
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