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Decoding the Snail transcriptional network: its role in cancer progression and therapy

Abstract The transcription factor Snail is a central regulatory hub that governs the transition from localized tumorigenesis to invasive, metastatic, therapy-resistant disease. Elucidating the mechanisms of Snail-driven epithelial-mesenchymal transition (EMT) and identifying strategies to target thi...

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שמור ב:
Principais autores: S. E. Parfenyev, A. N. Nazarov, A. A. Daks, O. A. Fedorova, N. A. Barlev, O. Y. Shuvalov
פורמט: Artigo
שפה:Inglês
יצא לאור: BMC 2026-05-01
סדרה:Biology Direct
נושאים:
Snail
Epithelial-mesenchymal transition (EMT)
E-box
Cancer stem cells (CSCs)
EGR1/SP1
Therapy resistance
גישה מקוונת:https://doi.org/10.1186/s13062-026-00751-1
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