BRIT1/MCPH1 is essential for mitotic and meiotic recombination DNA repair and maintaining genomic stability in mice.

BRIT1 protein (also known as MCPH1) contains 3 BRCT domains which are conserved in BRCA1, BRCA2, and other important molecules involved in DNA damage signaling, DNA repair, and tumor suppression. BRIT1 mutations or aberrant expression are found in primary microcephaly patients as well as in cancer p...

ver descrição completa

Detalhes bibliográficos

Principais autores:	Yulong Liang, Hong Gao, Shiaw-Yih Lin, Guang Peng, Xingxu Huang, Pumin Zhang, John A Goss, Francis C Brunicardi, Asha S Multani, Sandy Chang, Kaiyi Li
Formato:	Artigo
Idioma:	Inglês
Publicado em:	Public Library of Science (PLoS) 2010-01-01
coleção:	PLoS Genetics
Acesso em linha:	https://journals.plos.org/plosgenetics/article/file?id=10.1371/journal.pgen.1000826&type=printable
Tags:	Adicionar Tag Sem tags, seja o primeiro a adicionar uma tag!