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Preliminary mechanistic study of mitochondrial function in intestinal protection mediated by high-energy X-ray FLASH radiotherapy

Abstract Purpose Ultra-high dose rate (UHDR) radiation retains tumor-killing efficacy while mitigating toxicity to normal tissues, holding a promising transformative radiotherapy paradigm. This study aimed to explore the potential role of mitochondria in intestinal protection conferred by high-energ...

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Main Authors: Xiaofei Hao, Huan Du, Binwei Lin, Decai Wang, Wei Wu, Mingming Tang, Huayan Zhang, Yihan Zhu, Yu Zhang, Yiwei Yang, Xiaobo Du
Format: Artigo
Language:Inglês
Published: BMC 2026-02-01
Series:Radiation Oncology
Subjects:
Ultra-high dose rate
X-ray
FLASH effect
Intestine
Mitochondria
Metabolism
Online Access:https://doi.org/10.1186/s13014-026-02809-w
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