Synthetic DNA barcodes identify singlets in scRNA-seq datasets and evaluate doublet algorithms

Summary: Single-cell RNA sequencing (scRNA-seq) datasets contain true single cells, or singlets, in addition to cells that coalesce during the protocol, or doublets. Identifying singlets with high fidelity in scRNA-seq is necessary to avoid false negative and false positive discoveries. Although sev...

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Hlavní autoři:	Ziyang Zhang, Madeline E. Melzer, Keerthana M. Arun, Hanxiao Sun, Carl-Johan Eriksson, Itai Fabian, Sagi Shaashua, Karun Kiani, Yaara Oren, Yogesh Goyal
Médium:	Artigo
Jazyk:	Inglês
Vydáno:	Elsevier 2024-07-01
Edice:	Cell Genomics
Témata:	single-cell genomics lineage tracing barcoding singlets doublet detection machine learning
On-line přístup:	http://www.sciencedirect.com/science/article/pii/S2666979X24001769
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