Flagellin-fused protein targeting M2e and HA2 induces potent humoral and T-cell responses and protects mice against various influenza viruses a subtypes

Abstract Background Current influenza vaccines are mainly strain-specific and have limited efficacy in preventing new, potentially pandemic, influenza strains. Efficient control of influenza A infection can potentially be achieved through the development of broad-spectrum vaccines based on conserved...

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Principais autores:	Liudmila A. Stepanova, Eugenia S. Mardanova, Marina A. Shuklina, Elena A. Blokhina, Roman Y. Kotlyarov, Marina V. Potapchuk, Anna A. Kovaleva, Inna G. Vidyaeva, Alexandr V. Korotkov, Elizaveta I. Eletskaya, Nikolai V. Ravin, Liudmila M. Tsybalova
Formato:	Artigo
Idioma:	Inglês
Publicado em:	BMC 2018-04-01
coleção:	Journal of Biomedical Science
Assuntos:	Influenza virus Universal vaccine M2e ectodomain HA2 Flagellin Recombinant protein
Acesso em linha:	http://link.springer.com/article/10.1186/s12929-018-0433-5
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